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2 edition of Prognostic value of morphometry of chronic damage in renal biopsy specimens found in the catalog.

Prognostic value of morphometry of chronic damage in renal biopsy specimens

Maria Alice Sperto Ferreira

Prognostic value of morphometry of chronic damage in renal biopsy specimens

by Maria Alice Sperto Ferreira

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Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.D.) - University of Birmingham, Department of Pathology, School of Medicine, Faculty of Medicine and Dentistry.

Statementby Maria Alice Sperto Ferreira.
The Physical Object
Pagination1various p.aging
ID Numbers
Open LibraryOL19052567M

  diabetic nephropathy; renal biopsy; morphometry; prognosis; The diagnosis of CKD is typically made on the basis of interpretations of reduced renal function (using the Modification of Diet in Renal Disease eGFRkidney damage, the presence of small kidneys on imaging, or oliguria ().The natural decline in renal function in adults (aged >30–40 years) is usually Author: Susanne B. Nicholas. This handbook provides a short, clear, useful and interesting guide to the findings in renal biopsy specimens. It is intended to be of practical help primarily to pathologists and trainee pathologists who look at these specimens, but also to nephrologists and transplant surgeons and their trainees, medical students, and others who have contact with anyone with renal disorders, including nurses.

  Prognostic value of cytoreductive nephrectomy combined with targeted therapy for metastatic renal cell carcinoma: a meta-analysis. Int Urol Nephrol. 48, –75 (). CASCited by: 3. Evaluation of biopsy specimens was performed by a single pathologist (FML). Morphometry study. Additional sections (5 μm thick) of renal biopsy specimens were stained with Jones' silver stain. Morphometry analysis of renal scarring was performed using computerized image analysis, as described by Bruneval et al. Briefly, a Qwin Pro image.

The natural history of renal allograft damage has been characterized in serial protocol biopsies. The prevalence of subclinical rejection (SCR) is maximal during the first months and it is associated with the progression of interstitial fibrosis/tubular atrophy (IF/TA) and a decreased graft survival. IF/TA rapidly progress during the first months and constitutes an independent predictor of Cited by: Injury score (IS) is a marker of chronic damage and has recently been shown to have prognostic value in focal segmental glomerulosclerosis [29]. It is calculated as IS = (number of segmental sclerotized glomeruli + number of globally sclerotized glomeruli)/total number of glomeruli + IFTA (expressed as an absolute number).


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Prognostic value of morphometry of chronic damage in renal biopsy specimens by Maria Alice Sperto Ferreira Download PDF EPUB FB2

An interactive image analysis system was used to outline and measure areas of chronic damage in renal biopsy specimens to give an index of chronic damage, expressed as a percentage of cortical cross‐sectional area.

Prognostic value was analysed by the Kaplan–Meier method to study time between biopsy and onset of permanent by: Howie AJ, Ferreira MAS, Adu D. Prognostic value of simple measurement of chronic damage in renal biopsy specimens.

Nephrol Dial Transplant ; – PubMed CrossRef Google ScholarAuthor: Alexander J. Howie. Chronic kidney disease (CKD) is defined as the presence of kidney damage or an estimated glomerular filtration rate (eGFR) less than 60 ml/min/ mt2, persisting for 3 months or more, irrespective of the cause.

It is a state of progressive loss of kidney function ultimately resulting in the need for renal replacement therapy (dialysis or transplantation).Author: Satyanarayana R. Vaidya, Narothama R. Aeddula. Idiopathic membranous glomerulonephritis (IMGN) represents approximately 20% of cases of nephrotic syndrome in adults.1, 2 Progression of the disease to renal death during the decade after renal biopsy has been variably estimated, but a figure of 30% is probably close to reality (for review, see 3).Several criteria predictive at presentation of an unfavorable course have been determined Cited by: We assessed the predictive value of the clinical, laboratory, and morphological data obtained at the time of diagnosis, established on the basis of kidney biopsy, for the prognosis of primary FSGS.

Predicting Kidney Function from Renal Biopsy. Semiquantitative Versus Quantitative Approach. prognostic value of interstitial inflammatory disease who developed chronic renal failure. Glomerular Density in Renal Biopsy Specimens Predicts the Long-Term Prognosis of IgA Nephropathy November Clinical Journal of the American Society of Nephrology 5(1) In studies of serial protocol biopsies, chronic damage progress, whereas serum creatinine remains stable, suggesting that histological damage precedes renal functional deterioration.

13 In a study of paired 4- and month protocol biopsies, chronic lesions significantly increased in all renal compartments, whereas mean serum creatinine Cited by: The aim of this study was to validate glomerular and tubulointerstitial morphometric prognostic factors, as well as clinical factors, in our cohort of patients with IMN.

Material and methods. We included patients having undergone kidney biopsy in two Nephrology Departments in Zagreb, Croatia, between andand diagnosed with by: 7. Genek, Atilla Uzum & Mustafa Cirit () Prognostic Value of NGAL Staining in Patients with IgA Nephropathy, Renal Failure, DOI: /X Prognostic Value of Renal Pathological Findings in Children With Atypical Hemolytic Uremic Syndrome Mitra Mehrazma,1 Nakisa Hooman,2 Hasan Otukesh2 Introduction.

Atypical hemolytic uremic syndrome (HUS) is accompanied by a poor prognosis and high mortality rate.

We investigated the predictive value of severity of renal involvement. The amount of chronic renal damage at the time of biopsy is likely to be related to the rate of loss of kidney function. In addition, some lesions may influence the rate of decline, as well as baseline by: Howie AJ, Ferreira MAS, Adu D.

Prognostic value of simple measurement of chronic damage in renal biopsy specimens. Nephrol Dial Transplant. ; –Cited by:   All chronic renal diseases result in the accumulation of extracellular matrix in the interstitium, referred to as fibrosis, which can eventually contribute to renal failure.

1 – 7 For this reason, assessment of interstitial fibrosis is widely used in the evaluation of kidney biopsies. 8 – 11 Several studies have shown that interstitial fibrosis quantification is predictive of renal Cited by: An interactive image analysis system was used to outline and measure areas of chronic damage in renal biopsy specimens to give an index of chronic damage, expressed as a percentage of cortical.

The predictive value of interstitial scarring on a renal biopsy for poor outcome is common to a variety of chronic renal diseases,as well as lupus nephri Importantly, Howie et al 29 recently reported a more subjective, semiautomated system for measuring scarring in periodic acid-Schiff (PAS)-stained renal biopsies Cited by: An Algorithmic Approach to Renal Biopsy Interpretation of Glomerular Diseases J.

Charles Jennette, MD Brinkhous Distinguished Professor and Chair of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill, Chapel Hill, NC, USA The diagnosis of glomerular disease in renal biopsy specimens often has at least 5 steps that.

Prognostic value of simple measurement of chronic damage in renal biopsy specimens. Nephrol Dial Transplant. ; View in ArticleCited by:   Tens of thousands of native kidney biopsies are performed annually across the world for the evaluation and management of a variety of forms of kidney disease.

1, 2 Information from pathologic examination of biopsy tissue is used for diagnosis as well as prognosis. 3 – 5 Despite the importance of the kidney biopsy in the care of patients with acute kidney diseases and CKDs, 6 there are no Cited by: Long‐term prognostic value of ultrastructural features in dilated cardiomyopathy: comparison with cardiac magnetic resonance This study aims to determine the implications associated with long‐term prognosis of heart failure (HF) in patients with dilated cardiomyopathy (DCM) presenting initially as decompensated HF.

Biopsy specimens Author: Tsunenori Saito, Kuniya Asai, Masaki Tachi, Shigeru Sato, Kosuke Mozawa, Akiko Adachi, Yoshihiro Sas. Background and objectives: An early histopathologic predictor of the renal prognosis, before the occurrence of advanced glomerular sclerosis/interstitial fibrosis and/or apparent renal dysfunction, remains to be established in IgA nephropathy (IgAN).

This study aimed to determine whether the glomerular density (GD; nonsclerotic glomerular number per renal cortical area) of biopsy specimens Cited by: Figure 1 Progression to end-stage renal failure (ESRF) stratified by rate of decrease in index of chronic damage between the first and last renal biopsy specimens (P Cited by: Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by notable interpatient heterogeneity.

There have been important advances in therapy and overall survival, but some patients with high-risk features still have poor survival rates. Therefore, accurate identification of this subset of patients has been integral to improvement of patient outcome.

During the last few years Cited by: 6.